Skip to main content

Plasma IgG antibody against cytomegalovirus but not herpes simplex virus is associated with recurrence of atrial fibrillation after catheter ablation

The precise mechanism of atrial fibrillation (AF) remains uncertain but suggested to be correlated with pathogenic infection. This study sought to determine the role of viral pathogens, herpes simplex virus (HSV)-1, HSV-2, and cytomegalovirus (CMV), in AF recurrence after radiofrequency catheter ablation in a strictly selected patient population. A total of 4148 patients undergoing AF catheter ablation were screened for structural heart diseases and known risk factors for AF, and the resultant 103 patients (74 paroxysmal and 29 persistent) were recruited. Pre-ablation clinical and laboratory data and viral-specific IgG antibody levels were compared with those in 72 healthy control subjects. Plasma concentrations of the antibodies were all significantly elevated in AF patients (P < 0.001 vs. control). During a mean follow-up of 12.8 ± 7.0 months, 29 (28.2%) patients had AF recurrence. Patients who experienced AF recurrence had a significantly higher concentration of baseline anti-CMV, but not anti-HSV, IgG antibody than non-recurrent patients in the overall AF population (P= 0.01) and in subgroup analysis of persistent AF patients (P < 0.001). Multivariate Cox regression analysis indicated that anti-CMV level independently predicted post-ablation AF recurrence in both the overall AF patients [hazard ratio (HR) 1.013, P = 0.029] and persistent AF patients (HR 1.034, P = 0.043). Circulating anti-CMV IgG level may have important prognostic value in determining AF recurrence in post-ablation patients beyond established risk factors.



from European Heart Journal Supplements - current issue http://ift.tt/1LsTcFZ
via IFTTT
Labels:

Popular posts from this blog

Photo

from Bodybuilding Motivation http://ift.tt/2EtKRn5 via IFTTT
Read more

Hany Rambod's Ultimate Guide To FST-7

What do the bodybuilding greats of our time all have in common? A style of training that showed them the limitless potential of their physique. Here's what you need to know about FST-7. Hany Rambod's nickname is "The Pro Creator." He's watched his protégés take home the ultimate prize at the Olympia Weekend 15 times—including three on a single night in 2014. Far more times than that, he's watched his clients push their already impressive physiques where they never thought possible. The way he did it is no mystery. Rambod's clients all followed FST-7, or "fascia-stretch training," his signature training style. Do it right, and it can substantially change both the size and shape of your muscles. Just don't expect it to be easy or painless. If you've wondered what all the fuss is about, Rambod has created a video explaining the fundamentals of FST-7, along with tips on how to scale it for everyone from beginners to advanced lifters and h...
Read more