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Showing posts from April, 2016

A chemical approach to myocardial protection and regeneration

The possibility of generating induced pluripotent stem cells from mouse embryonic fibroblasts and human adult fibroblasts has introduced new perspectives for possible therapeutic strategies to repair damaged hearts. However, obtaining large numbers of adult stem cells is still an ongoing challenge, and the safety of genetic reprogramming with lenti- or retro-viruses has several drawbacks not easy to be addressed. Furthermore, the majority of adult stem cell-based clinical trials for heart regeneration have had generally poor and controversial results. Nonetheless, it is now clear that the injected cells activate the growth and differentiation of progenitor cells that are already present in the heart. This is achieved by the release of signalling factors and/or exosomes carrying them. Along this line, chemistry may play a major role in developing new strategies for activating resident stem cells to regenerate the heart. In particular, this review focuses on small molecule approaches for

Surgical ventricular reconstruction for ischaemic heart failure: state of the art

Patients with ischaemic cardiomyopathy and left ventricular (LV) systolic dysfunction represent the highest-risk population with heart failure (HF). The cornerstone of treatment remains guideline-driven medical therapy, which is associated with significant improvement in survival and quality of life. The most commonly considered surgical interventions are coronary artery bypass graft surgery, at times combined with surgical ventricular reconstruction (SVR) and surgery for mitral valve regurgitation. Surgical ventricular reconstruction has been introduced as an optional therapeutic strategy aimed to reduce LV volumes through the exclusion of the scar tissue, thereby restoring the physiological volume and shape and improving cardiac function and clinical status. This review will briefly discuss the rationale to surgically reverse LV remodelling, the technique, and the indications, to the best of our knowledge, coming from the Center with the largest worldwide experience. The evolving dat

The care for adults with congenital heart disease: organization and function of a grown-up congenital heart disease unit

Thanks to the improvement of surgical and interventional cardiac procedures, the majority of children with congenital heart defects (CHD) can now be expected to reach adulthood. The number of adults with congenital heart disease (ACHD) will inevitably increase, and recent data affirm that in Europe, we are actually faced with an estimated patient population of 2.3 million. These patients, particularly the adults with moderate and highly complex CHD, can be very difficult to manage, and should be treated in few experienced and specialized ‘grown-up congenital heart disease’ (GUCH) units, concentrating resources, patients, funding, and professional experiences. On 2000, we created a GUCH unit in our hospital that rapidly became a referral centre in Italy for number and complexity of patients treated. The present study is a presentation of how is organized our GUCH unit and a brief overview of our more recent experience with ACHD patients. from European Heart Journal Supplements - curr

Rhinocerebral zygomycosis: an unusual dramatic presentation in a paediatric cardiac patient without risk factors

Mucormycosis is an angioinvasive infection caused by ubiquitous filamentous fungi of the order Mucorales. We describe a case of rhinocerebral mucormycosis presented in a paediatric patient after cardiac surgery correction of a complete atrioventricular canal defect. The rhinocerebral form of mucormycosis in our patient presented as an important epistaxis that needed immediate intubation due to blood inhalation. Furthermore, due to the worsening of pulmonary function, the patient also needed mechanical support with veno-arterial extracorporeal membrane oxygenation. The patient died as a consequence of a disseminated form of fungal infection. We describe our experience of this rare opportunistic infection and we think that early recognition of the disease could help in proper management. from European Heart Journal Supplements - current issue http://ift.tt/249QoGk via IFTTT

Treatment of right ventricular outflow tract dysfunction: a multimodality approach

The right timing to replace the pulmonary valve in a patient with dysfunction of the right ventricular outflow tract is unknown. Both percutaneous pulmonary valve and surgical prosthesis are suitable options. In every patient, the right ventricle (RV) remodels and recovers differently after pulmonary replacement. Therefore, it is difficult to identify the best treatment option and to predict the long-term results. In the last few years, we focused our research on optimizing the characterization of these patients through advanced cardiovascular imaging in order to find possible variables, parameters, and reproducible measurements that can help us in the decision-making process. The aim of the present article is to present our ongoing research lines that focus on the characterization and optimal treatment approach to the dysfunction of the RVOT. from European Heart Journal Supplements - current issue http://ift.tt/1QFpZmZ via IFTTT

Multimodality cardiac imaging at IRCCS Policlinico San Donato: a new interdisciplinary vision

Multimodality imaging is the efficient integration of various methods of cardiovascular imaging to improve the ability to diagnose, guide therapy, or predict outcome. This approach implies both the availability of different technologies in a single unit and the presence of dedicated staff with cardiologic and radiologic background and certified competence in more than one imaging technique. Interaction with clinical practice and existence of research programmes and educational activities are pivotal for the success of this model. The aim of this paper is to describe the multimodality cardiac imaging programme recently started at San Donato Hospital. from European Heart Journal Supplements - current issue http://ift.tt/249QopU via IFTTT

microRNAs in ischaemic cardiovascular diseases

microRNAs (miRNAs) are non-coding RNA molecules that modulate the stability and/or the translational efficiency of specific messenger RNAs. They have been shown to play a regulatory role in most biological processes and their expression is disrupted in many cardiovascular diseases. This review describes studies performed at Policlinico San Donato-IRCCS in cell cultures, animal models, and patients, showing a penetrant role of miRNAs in cell response to hypoxia and in ischaemic cardiovascular diseases. These experiments indicate miRNA as an emerging class of therapeutic targets. from European Heart Journal Supplements - current issue http://ift.tt/1QFq1LG via IFTTT

New technologies in vascular surgery: San Donato's experience in the last decades

The Department of Vascular Surgery I at IRCCS Policlinico San Donato has been part of the Cardiovascular Center "Edmondo Malan" since the end of the 1980s. Surgical activity of the Department has always been designed to prevent and treat vascular diseases such as aneurysms of the thoracic and abdominal aorta and peripheral vessels, carotid artery stenosis, peripheral arterial disease, and chronic venous insufficiency. Excellent results have been achieved with the endovascular treatment of both symptomatic and asymptomatic carotid artery stenosis also by using innovative devices. Another point of interest regards the endovascular treatment of more complex thoraco-abdominal aortic aneurysms. We report our experience in the last decades. from European Heart Journal Supplements - current issue http://ift.tt/249Qo9B via IFTTT

Point-of-care haemostasis and coagulation monitoring in cardiac surgery at IRCCS Policlinico San Donato

A rational management of perioperative and postoperative bleeding in modern cardiac surgery requires a thorough application of point-of-care (POC) monitoring in order to prevent and readily treat alterations of the haemostatic process. Preoperative platelet dysfunction, residual heparin after extracorporeal circulation, coagulation factors, and/or fibrinogen deficiency could be ruled out and specifically addressed with an appropriate treatment. Our approach includes preoperative platelet function testing of patients administered with thienopyridines or ticagrelor within 7–10 days before planned surgery and platelet function testing-based surgery timing. In the case of postoperative bleeding, residual heparin is tested and additional protamine is eventually administered. Simultaneously, an overall activity of coagulation factors (except fibrinogen) is assessed and, if significantly reduced, correction with prothrombotic complex concentrate is considered. If fibrinogen deficiency is susp

Fractional flow reserve based on computed tomography: an overview

Computed tomography coronary angiography (CTCA) is a technique proved to provide high sensitivity and negative predictive value for the identification of anatomically significant coronary artery disease (CAD) when compared with invasive X-ray coronary angiography. While the CTCA limitation of a ionizing radiation dose delivered to patients is substantially overcome by recent technical innovations, a relevant limitation remains the only anatomical assessment of coronary stenoses in the absence of evaluation of their functional haemodynamic significance. This limitation is highly important for those stenosis graded as intermediate at the anatomical assessment. Recently, non-invasive methods based on computational fluid dynamics were developed to calculate vessel-specific fractional flow reserve (FFR) using data routinely acquired by CTCA [computed tomographic fractional flow reserve (CT-FFR)]. Here we summarize methods for CT-FFR and review the evidence available in the literature up to

Activities at Thoracic Aortic Research Center, IRCCS Policlinico San Donato

The Thoracic Aortic Research Center (TARC) of the IRCCS Policlinico San Donato (PSD) aims to promote research on thoracic aortic diseases, to disclose the scientific knowledge and clinical experience and to develop new scientific paths within the Hospital and the aortic community, in collaboration with other national and international centres. Thoracic Aortic Research Center collaborates with many centres in both Europe (e.g. University of Utrecht, the Netherlands) and the USA (e.g. University of Michigan). This has led to multiple highly regarded publications in respected cardiovascular journals and has led to several PhD programmes resulting in doctorate degrees. Within Italy, in association with the Bioengineering School of the University of Pavia, TARC has founded the "BETA-lab" ( B iomechanics for E ndovascular T reatment of the A orta laboratory), where MDs, Bioengineers, and PhD fellows conduct experimental studies using in vitro/ex vivo models of the physiologic aort

Novel cardiac magnetic resonance biomarkers: native T1 and extracellular volume myocardial mapping

Cardiac magnetic resonance (CMR) is a non-invasive diagnostic tool playing a key role in the assessment of cardiac morphology and function as well as in tissue characterization. Late gadolinium enhancement is a fundamental CMR technique for detecting focal or regional abnormalities such as scar tissue, replacement fibrosis, or inflammation using qualitative, semi-quantitative, or quantitative methods, but not allowing for evaluating the whole myocardium in the presence of diffuse disease. The novel T1 mapping approach permits a quantitative assessment of the entire myocardium providing a voxel-by-voxel map of native T1 relaxation time, obtained before the intravenous administration of gadolinium-based contrast material. Combining T1 data obtained before and after contrast injection, it is also possible to calculate the voxel-by-voxel extracellular volume (ECV), resulting in another myocardial parametric map. This article describes technical challenges and clinical perspectives of these

International cooperation in healthcare: model of IRCCS Policlinico San Donato and Bambini Cardiopatici nel Mondo Association for congenital heart diseases

Cooperation activity in training programmes promoted by IRCCS Policlinico San Donato and Bambini Cardiopatici nel Mondo Association is a model of cooperation between people as an alternative intervention in promoting the right to healthcare, especially offering programmes of training and medical care on cardiovascular and congenital heart disease. This new strategy, implemented in several developing countries, has absolutely contributed to the improvement of the medical services concerning the diagnostic and surgical approach in the treatment of paediatric and adult cardiovascular disease. To strengthen this kind of activity, both IRCCS Policlinico San Donato and Bambini Cardiopatici nel Mondo have introduced a global perspective aiming at the realization of surgical missions ‘in situ’, building new cardiac surgery units in collaboration with the local partners, which are mainly university hospitals. They, furthermore, support financially the scholarship and accommodation in favour of

Modern ECMO: why an ECMO programme in a tertiary care hospital

Extracorporeal Membrane Oxygenation (ECMO) represents a useful tool to support the lungs and the heart when all conventional therapies failed and the patients are at risk of death. While the Extracorporeal Life Support Organization (ELSO) collects data from different institutions that joined the Registry and reports overall outcome, individual centres often collide with results below expectations, either in adults and in paediatric population. Some authors suggest that poor outcomes could be overcome with a programme dedicated to ECMO, with specialized professionals adequately trained on ECMO and with a consistent number of procedures. In 2012, The IRCCS PSD ECMO Programme was instituted with the specific aim of achieving better results than hitherto obtained. After only 1 year of activity, the results justified the programme, with a better survival rate for each group investigated, particularly in adults, but surprisingly in paediatrics too, where the results were better than what rep

Transcatheter aortic valve replacement--state of the art and a glimpse to the future: 'the Tailored Approach

Transcatheter aortic valve replacement determined a paradigm shift in the treatment of high-risk patients with severe symptomatic aortic valve stenosis. Notwithstanding the impressive results of the first-generation prostheses, a fast-paced technological evolution is taking place to overcome their limitations, in particular the vascular access damage and the paravalvular leak. Nowadays, with the availability of several different devices, the expert operator can select the right prosthesis for the specific anatomical and clinical situation. As ‘One does not fit all’, the ‘Tailored TAVR Approach’ we describe will conceivably become the future of this therapy. from European Heart Journal Supplements - current issue http://ift.tt/1QFpWaE via IFTTT

Kerry Group reports growth in business volumes

Kerry Group has posted a 2.9% growth in business volumes, driven by its Taste & nutrition and Consumer food divisions in first quarter results, thanks partly to its children‘s snack product Cheestrings. from NutraIngredients RSS http://ift.tt/1rmuNZN via IFTTT

Monsanto slams EU attempt to block GM crops in Africa as 'neo-colonialism'

The European Parliament’s Committee on Development has urged G8 member states “not to support GMO [genetically modified] crops in Africa” as part of its critical resolution on the New Alliance for Food Security and Nutrition - a decision agri giant Monsanto has called anti-business and neo-colonialist.  from NutraIngredients RSS http://ift.tt/24nRFq2 via IFTTT

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Probiotic strains for dairy added by Probi

Probi has strengthened its functional food offer after acquiring a licence for two probiotic strains for use in food applications, primarily dairy, from fellow Swedish biotech company Probac. from NutraIngredients RSS http://ift.tt/26veKcv via IFTTT

Dairy Council issues booklet on iodine in dairy

Certain groups of the UK population are classified as mildly iodine deficient, however, according to The Dairy Council, consuming milk, yogurt and cheese can help ensure that iodine requirements are met. from NutraIngredients RSS http://ift.tt/1NUtZjC via IFTTT

Omega-3 Fish Oil Supplements Might Boost Antidepressants' Effects

Data from 8 randomized clinical trials suggests a benefit, but consult with your doctor first, experts say Source: HealthDay from Dietary Supplements New Links: MedlinePlus RSS Feed http://ift.tt/24jSsbJ via IFTTT

Olive-sourced hydroxytyrosol effective in biscuits: Study

Olive oil phenol hydroxytyrosol has been shown to be highly bioavailable and to lower oxidised LDL (low density lipoprotein) levels when incorporated into biscuits, suggesting functional food applications could be on the horizon for this EFSA-backed polyphenol.  from NutraIngredients RSS http://ift.tt/2367E9O via IFTTT

Seaweed market boosted by NPD surge

Food and drink product launches with seaweed flavours, including kombu, nori, and wakame, grew by 147% in Europe between 2011 and 2015, according to latest figures. from NutraIngredients RSS http://ift.tt/1TcceOz via IFTTT

How to shut down the illicit ginkgo trade

Research into the adulteration and poor manufacturing practices of ginkgo products has highlighted the need to reign in unregistered food supplements containing the botanical.  from NutraIngredients RSS http://ift.tt/24hits8 via IFTTT

Raw foods on the rise as clean-label consumers crave more

From snack bars to spreads, chocolate to cheese, the trend for raw ingredients in processed foods is spreading across Europe, says Mintel, as consumer attention goes beyond the ingredient list to look at clean-label processing methods. from NutraIngredients RSS http://ift.tt/26pIck2 via IFTTT

Probiotics expert: 'Disband EFSA' and end destructive category confusion

A leading probiotics academic has called for EFSA to be  “disbanded”  saying that the effect of the EU’s central food science agency’s treatment of probiotic claims has been  “confusion in Europe”,  and that the EU could learn from the Canadian approach to probiotic regulation. from NutraIngredients RSS http://ift.tt/26pIcjU via IFTTT

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Dietary fibre intake suppresses appetite

Big opportunities exist for food manufacturers to tackle obesity through the use of food containing non-digestible inulin fibre to encourage satiety, according to a leading academic. from NutraIngredients RSS http://ift.tt/1WKRaEm via IFTTT

Folic acid fortification: The current global state of play

To date 75 countries globally have implemented mandatory fortification programmes for folic acid with the aim of preventing neural tube defects (NTDs) in babies. Yet despite growing calls from NGOs, health experts and researchers, the 28 EU member countries are notably absent from the list.  from NutraIngredients RSS http://ift.tt/1So3gxK via IFTTT

How to take the sleaze out of libido supplements

The market for male libido supplements dwarfs that for women – but positioning products as healthy ageing supplements may help shake the sleaze from this niche segment, says one bawdy botanical supplier. from NutraIngredients RSS http://ift.tt/23NxyVx via IFTTT

1000 Holland & Barrett franchise stores to open in India

Health and nutrition retailer Holland & Barrett has secured a £20m (€25.44m) deal with Indian hospital chain Apollo Hospitals, an agreement which will see 1000 franchise stores open across India over the next five years. from NutraIngredients RSS http://ift.tt/1QqHBCP via IFTTT

Venture capital fund seeks start-ups: Must be sustainable innovative & ready to make money

New Crop Capital is a venture capital fund that only invests in sustainable start-ups developing cultured and plant-based meat, dairy and egg products. But it's not just about saving the planet:  “There are billions to be made annually in this space,” it says. from NutraIngredients RSS http://ift.tt/1r0aMs3 via IFTTT

Barentz backs water lentils for protein

Dutch ingredients player Barentz International has partnered with Floridian biotech start-up Parabel USA to globally distribute ‘water lentil’-derived protein. from NutraIngredients RSS http://ift.tt/1S6QYgD via IFTTT

BHF backs vitamin K heart health research

The British Heart Foundation (BHF) has invested £290,000 (€365,000) in a vitamin K trial investigating its potential to reduce heart problems in people with chronic kidney disease (CKD). from NutraIngredients RSS http://ift.tt/1qvkNNg via IFTTT

Berry drink shows skin benefits

A polyphenol-rich red and black currant berry drink has shown significant anti-wrinkle and skin smoothing benefits in a 12-week French study. from NutraIngredients RSS http://ift.tt/1W4KvnF via IFTTT

4 probiotic strains found in kimchi

South Korean researchers have isolated four potentially ‘useful’ probiotic strains in traditional Korean fermented food kimchi.  from NutraIngredients RSS http://ift.tt/1qvkPor via IFTTT

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Personalised nutrition ‘really works’: new research

New EU research shows that diets targeted at an individual’s specific needs –personalised nutrition – can improve health more than general nutrition advice, but the results are not improved by honing that advice based on people's phenotype (physiological characteristics) or genetic (DNA) make-up. from NutraIngredients RSS http://ift.tt/1T3GhdF via IFTTT

Novel regulation - same old delays? Stakeholders express novel food process concerns

The updated novel food regulation has been billed by the European Commission as a new streamline system that will put innovation back on the EU menu – yet attendees of a stakeholders meeting this week expressed concern these hopes would be dashed by duplication and delays. from NutraIngredients RSS http://ift.tt/1S4CGtq via IFTTT

Wageningen University & FrieslandCampina researching 3D printing of milk protein structures

3D food printing gives academics an opportunity to explore the functionality of ingredients and how we can delay the process to get a solid structure and build challenging shapes, according to Dr Maarten Schutyser, professor, Food Process Engineering, Wageningen University. from NutraIngredients RSS http://ift.tt/1VS31Q9 via IFTTT

Food Vision Asia: Be part of a unique EU delegation

Are you looking to explore the Asian market for new business opportunities? Food Vision Asia is looking for individuals who are interested in forming a delegation to represent Europe’s trade interests, and form new commercial relationships within Asia’s food and nutrition sector. from NutraIngredients RSS http://ift.tt/1RPU1tn via IFTTT

French find fault in 4 or 5-class nutrient profiling

The French food safety agency (ANSES) has concluded two nutrient profiling systems won’t provide people with easily understandable grading of food into four or five classes depending on their healthiness. from NutraIngredients RSS http://ift.tt/1SVAGpI via IFTTT

GOED recommends 500 mg of Omega-3 daily

Russia recommends 1,300 mg of Omega-3 EPA and DHA per day, while most countries recommend around 250 mg. After years of deliberation, GOED finally released its own recommendation: 500 mg a day. from NutraIngredients RSS http://ift.tt/1NdxIIM via IFTTT

Naturex adds chokeberry to botanicals range

Naturex has added a proprietary aronia extract to its library after inking a licensing deal with Polish food supplements and OTC player Adamed Consumer Healthcare SA. from NutraIngredients RSS http://ift.tt/25NFN2i via IFTTT

Survey blasts industry & EU for allowing unhealthy foods to make health claims

What’s the difference between a chocolate bar and an apple? Not much if you go by the misuse of health claims on food in Germany and the Netherlands says campaign group FoodWatch, after evaluating over 600 products making prominent claims to be healthy, finding that 80% were high in sugar, salt or fat. from NutraIngredients RSS http://ift.tt/1WdxWa1 via IFTTT

Backroom Brussels? Report calls for EU lobbying clampdown

A transparency watchdog has called for legally-binding measures to tackle lobbying in the EU, following the release of its report that claimed permanent representations for member states were being left wide open to corporate pressure. from NutraIngredients RSS http://ift.tt/1WdxUiA via IFTTT

Norwegians enter chitosan space

Norwegian supplier Marealis is working with fisheries R&D enterprise Nofima and set to enter the EU health claim-backed, cholesterol-controlling space with a shrimp shell extract. from NutraIngredients RSS http://ift.tt/1N8MBMz via IFTTT

UN declares Decade of Action on Nutrition

The United Nations (UN) General Assembly has declared a ‘Decade of Action on Nutrition’, placing nutrition firmly at the heart of its sustainable development agenda. from NutraIngredients RSS http://ift.tt/22710zA via IFTTT

Vitamin A prices set to continue to soar

After more than a year-long slump, China’s important vitamin A market is finally starting to rebound, with prices expected to continue to grow until the second-half 2016, according to market analyst CCM . from NutraIngredients RSS http://ift.tt/1V5620d via IFTTT

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EFSA budget plateaus despite growing workload

The European Food Safety Authority (EFSA) has announced plateauing budgets for the next three years and staffing reductions of 10% running up to 2018 – despite its increasing responsibilities. from NutraIngredients RSS http://ift.tt/1N1Zxne via IFTTT

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